Abstract: The one-sided water stopping curtain has been applied in construction near the water body, but there is lack of systematic research and specification references in the design of relevant parameters. Based on the actual project, Modflow numerical simulation software is used to establish the pumping drawdown model under the one-sided water stopping curtain. The orthogonal test and design parameter optimization research are carried out in terms of the four factors affecting the water isolation effect of the one-sided water stopping curtain, including the pile length,pile diameter, permeability coefficient and engineering boundary distance. The results show that the pile length is the most significant factor affecting the water isolation effect of the water stopping curtain, followed by the distance between the water stopping curtain and the underground works; comprehensively considering the project cost and ecological environment, it is suggested that the length of the pile should be 0.7~0.8 times as much as the thickness of the phreatic aquifer, and the distance from the underground works should be less than 0.1 times of the distance between the large-scale water body and the underground works. Moreover, on the premise of meeting the design and construction feasibility requirements, it is more economical and reasonable to choose the single-row multi-head small-diameter deep mixing pile.