Abstract: In order to meet the needs of grouting reinforcement and treatment in karst collapse areas, solid wastes such as red mud and steel slags are selected to prepare high-performance red mud-based grouting reinforcement materials and to establish methods for regulating properties such as setting time, mechanical strength and swellability. The test results show that the change in cement content has the greatest influence on the 7 d compressive strength of stones. The 7 d compressive strength of red mud-based grouting reinforcement materials shows a trend of increasing first and then decreasing with the increase of cement content. When the single factor acts, the strength is the highest when the cement content is 15%. Combined with the influence of single factors on the final setting time of grout and the 7 d mechanical strength of stones, it can be determined that the red mud-based grouting reinforcement materials have the best performance and excellent fluidity when the cement content is 15%, the steel slag content is 15% and the activator content is 12%. Considering the final setting time and mechanical strength of red mudbased grouting reinforcement materials, it is determined that the optimal mixing amount of each kind of expansive agent is 6% of UEA expansive agent, 6% of CSA expansive agent and 0.2% of the plastic expansive agent.