Abstract: Current research on the leakage range of pressurized water supply pipelines in sandy clay strata and the interaction between pipeline leakage and shield tunnelling that induces ground deformation is still inadequate to meet engineering needs. To address this, a combination of model tests and numerical simulations was used to explore the leakage impact range, ground deformation mechanisms, and disaster prevention and control measures under the interaction of pipeline leakage and shield tunnelling. Various parameters, including pipeline water pressure and leakage duration, were tested under multiple working conditions in the pressurized pipeline leakage model experiment. Results indicate that the leakage range increases exponentially over time, and the degree of change is positively correlated with water pressure. Furthermore, a refined finite element numerical model considering the effects of pipeline leakage was established to study the impact of leakage duration and other factors on tunnel and surrounding soil deformation, leading to corresponding disaster prevention measures.