Abstract: Traditional finite element method has been successfully applied in the analysis of the capability against uplift of pipelines, but it didn’t give the safety factors of the anti-uplift stability relating to the buried depth of pipelines. An ABAQUS model of anti-uplift of pipelines was established by using strength reduction method to take a two-dimensional numerical simulation of the behaviors of river-crossing pipelines under the effect of buoyancy, to observe the development process of plastic zone of soils and to determine the safety factor of anti-uplift stability.The results show that the factors of anti-uplift capability increase linearly as the function of the buried depth and the slope is governed by the friction angle of soil mass; equivalent values of and used in gravity analysis method, which may be taken as the applicable conditions in practical application cases, are obtained by comparing with the traditional gravity analysis method.