Abstract: Support-structure integrated pipe-roof pre-construction method is a new mined construction method in? tegrating reinforcement, supporting and major structure. At present the aseismic research on underground structure mainly involves in analyzing the seismic response of underground structure built by traditional construction technology and there is few seismic research of structure by large-section pipe-roof pre-construction method. Based on finite difference software FLAC3D, it studied the seismic response of metro station by pipe-roof pre-construction method. The results show that relative horizontal displacement of various measuring points along the height of station structure is in a shape of inversed S under the effect of strong earthquake; large stress of station structure under effect of earthquake often occurs at the junctions of various pipe-roofs, middle plate and pipe-roof as well as piperoof and base; compared with that under unidirectional earthquake effect, the acceleration and max. horizontal stress of station structure both increase and horizontal displacement and relative horizontal displacement decrease under bidirectional earthquake effect.