Abstract: To evaluate the seismic performance of a novel station structure employing strength-composite piles as permanent column supports, a three-dimensional numerical model of the entire structure was developed. The displacement, internal force, and acceleration responses at critical locations were evaluated under three representative horizontal seismic motions. In addition, the effects of critical parameters—including pile stiffness, rotational stiffness between piles, and rotational stiffness between the pile top and the longitudinal beam—on the seismic performance were systematically investigated. The results indicate that the maximum horizontal relative displacement occurs at the tops of the columns and side walls under seismic excitation. The maximum internal forces are concentrated at the junctions of the side walls and baseplates, as well as at the connections between the central columns and longitudinal beams. The most pronounced acceleration response is observed at the top slab. Among the input motions, the Taft wave has the most significant impact on the station structure, causing a maximum horizontal displacement of 16.97 mm and a maximum bending moment of 1 214.63 kN·m. The influence of stiffness parameters on horizontal displacement follows the order: pile stiffness > rotational stiffness between piles > rotational stiffness between the pile top and longitudinal beam. These findings provide valuable insights for the seismic design and construction of such structures in engineering practice.