Abstract: In order to study the seismic response law of two paralleled shield tunnels and interaction mechanism of tunnel-soil-tunnel system, the seismic response law of two paralleled shield tunnels with different parallel angles under Kobe wave and Beijing artificial wave was calculated and analyzed by MIDAS/NX finite element based on the Shenzhen metro line 13, with the results showing that spatial combinations of two paralleled tunnels amplifie dynamic response of soil mass compared with the single tunnel, especially the interlaid soils between tunnels with small interval; dynamic response of horizontally paralleled tunnels is the largest and it reveals this spatial combination is the most unfavorable mode regarding the aseismic design; internal force and deformation of the X-shaped region between two paralleled tunnels are the largest and it is the weak point in the aseismic design; according to the ratios of interval and diameter, the interaction region of tunnel- soil-tunnel are divided into three grades, i.e. severely affected area, moderately affected area and slightly affected area.