Abstract: GINA gasket is the waterproof lifeline of immersed tunnels. Based on the Hanjiang immersed tunnel in Xiangyang as the background, a full scale physical model test is conducted to study the compression, water tightness and stress relaxation of the domestic GINA gasket under various unfavorable conditions, and selection and design are carried out according to the test data. The research shows that: (1) compressive stress of the domestic GINA gasket gradually decreases with time and tends to stable converge, the 100-year average stress relaxation attenuation rate of domestic GINA gasket is about 35%; (2) with the increase of compression force, compression of GINA water stop tends to reach the limit value of its height by 60%, the allowable joint deflection will reduce the compressive stress of GINA water stop by 4.4%-9.2%; (3) the watertightness required minimum compression curve of domestic water stop is basically agree with that of a foreign product, with the deviation is about 0-15%; the watertightness required minimum compression increases slightly as for the joint with deflection angles of 0.1 and 0.22 degrees; in the case of vertical offset of joint by 1 cm, 3 cm, 5 cm and horizontal offset by 5 cm, no water leakage occurs and water tightness is not affected; (4) design of water stop should consider the joint opening and compression caused by the temperature change, concrete shrinkage and creep, uneven settlement of foundation, earthquake and so on under the normal and ultimate states of load capacity, and also meet the requirements for the minimum water tightness and the maximum compression; (5) performance of the domestic GINA water stop can meet the needs of the project and it has certain safety margin.