Abstract: It analyzes the anti-seismic technology of highway tunnel with super large section in fault fracture zone by 3D finite difference calculation software. Through numerical simulation, the influences of different stiffness of lining structures and grouting reinforcement means on the anti-seismic effet of tunnelling in fault fracture zone are analyzed. The results show that the stress of concrete lining with larger stiffness is larger, and the longitudinal influence range has a tendency of slightly increases; with the decrease of lining stiffness, the decrease trend of maximum principal stress is not linear and has an obvious trend of slow down, and the damping effect becomes less obvious after continuous reduction of lining stiffness; the grouting reinforcement has obvious anti-seismic effect on arch foot and haunch of the super large section tunnel in fault fracture zone, which will improve the condition of force on tunnel lining; the anti-seismic effect of full ring grouting at intervals is better than that of full ring contact grouting; it is suggested that grouting at intervals of 1 m and 4 m in thickness should be adopted at the fault fracture zone of the super large section tunnel.