Abstract: The Pearl River Delta Water Resources Allocation Project aims to solve the water supply problems in the Nansha district of Guangzhou, Shenzhen, Dongguan and other water-scarce areas, as well as the long-term water supply problems of cities in eastern Guangdong. As for the Shiziyang crossing section, it will be faced challenges such as fewer drilling holes, long distances, high water pressure, multiple faults, and large cross-sections. Combining the geological and hydrological conditions of the project, a Herrenknecht slurry balance shield with a diameter of 8.65 m is selected for construction and excavation, and the tunnel structure is designed with emphasis on waterproof and anti-corrosion. According to the stratum and engineering characteristics, the following construction suggestions are put forward: (1) before the project is carried out, the physical and mechanical characteristics of the fault fracture zones shall be explored, and the crossing plan should be fully prepared; (2) experimental research on the abrasiveness and composition of the rock and soil layer should be conducted to find out the wear rule of the cutter tool in the rock and soil layer; (3) new grouting materials need to be researched to form a material-theory integrated grouting system for crossing the fault zone.