Abstract: Addressing the construction challenges of large-diameter slurry balance shield tunnels passing through complex strata such as highly cohesive soil, breccia, and gravel, this paper presents targeted solutions in terms of shield equipment selection, equipment modification, and excavation control based on the river-crossing running tunnel between Guobo Center South Station and Lingwu Village Station of the Wuhan Metro Line 12. Field application results demonstrate that through increasing the cutterhead opening ratio, designing an inverted cone shaped central cutterhead area, and implementing multiple combined high-flow flushing, it can effectively solve the issue of cutterhead mud-caking in highly cohesive strata. And through multi measures, such as the targeted cutting tool configuration, lengthening of the mixing arm in the slurry chamber, and the addition of wear detection system, the slurry balance shield smoothly passed through breccia strata, improving the average penetration rate in this strata by approximately 247% after equipment modification. Furthermore, through adding a quarry box and an interactive duplex screening pipeline system, it effectively addressed the problem of pump blocking by large gravel blocks, ensuring continuous excavation in gravel strata. These targeted equipment modifications and construction measures significantly improved tunnelling efficiency, geological adaptability, and project safety during the construction of the running tunnel section between Guobo Central South Station and Lingwu Village Station of Wuhan Metro Line 12.