Abstract: Long and large highway tunnels are the core transportation infrastructure in Chongqing. In recent years, accidents relating to structural (facility) damage occur from time to time, so it is urgent to improve the operational safety and security capabilities. In this study, the accidents relating to structural (facility) damage to long and large tunnels in Chongqing were investigated, and the cause and form of accidents and risk sources were analyzed, the status of structural safety and security system was investigated and researched in terms of structural health maintenance and disaster-prevent and rescue system, the safety assurance system, measures, technical validity and real demands were defined, the difficulties and challenges suffered were analyzed, and the innovative operation management system and measures for disaster prevention and control, emergency rescue, etc. of long and large highway tunnels and the technical R&D and application were proposed in combination with emerging technologies. It is recommended to put forward three major action plans to build a secure guarantee system centered on "health monitoring/detection, advanced maintenance, smart disaster prevention, rapid emergency response, and comprehensive evaluation",help Chongqing become an international integrated transportation hub and a national (west China) science and tech? nology innovation center, promote the construction of a dual-city economic circle in Chongqing and Chengdu, and boost the safe development of our integrated three-dimensional transportation network.