Abstract: Based on the viscous-spring artificial boundary theory, a numerical model of a subway tunnel and soil foundation is established by seismic dynamic analogue simulation that considers the soil/structure dynamic interaction and wave effects. The dynamic response law of subway tunnels in strata that is interbedded with soft and hard soil layers under oblique incidence SV waves is analyzed systematically. The results show that: 1) seismic wave incident angle has a significant effect on the tunnel′s dynamic response and the dynamic response of the running tunnel decreases with an increase of the incident angle; 2) the dynamic response at the stratum interbedded with soft and hard soil layers is more obvious than that in other places under the same incident angle, which indicates this condition is unfavorable for seismic resistance; 3) the dynamic response of each point of the running tunnel tends to be consistent with decrease of the differences of the elastic modulus of soft and hard soil bodies; and 4) increasing the lining thickness reduces the displacement and bending moment of the tunnel structure at the connection of the soft soil body and the hard soil body, which increases the tunnel′s seismic behavior.